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View detailsCell-Free DNA Preservation Tube
Technical Specifications
Tube type: Evacuated blood collection tube
Volume: 10 mL
Additive: Proprietary liquid stabilization reagent (colorless, clear)
Storage & Stability
- Unopened tubes are stable at 4–30 °C until the expiration date printed on the label.
- Do not freeze or expose to temperatures above 37 °C prior to use.
- Once blood is collected, the stabilized sample can be held at 6–37 °C for up to 14 days without significant loss of cfDNA quality.
Product Description
The Cell-Free DNA Preservation Tube is a direct-draw blood collection tube specifically designed to stabilize cell-free DNA (cfDNA) in whole blood at room temperature. Its proprietary, formaldehyde-free additive immediately prevents cell lysis and nuclease activity, effectively inhibiting the release of contaminating genomic DNA (gDNA) from nucleated blood cells. This ensures that the original cfDNA profile – both in concentration and integrity – is preserved from venipuncture all the way to downstream analysis.
By removing the need for immediate plasma separation and cold-chain transport, the tube simplifies complex pre-analytical workflows in liquid biopsy, non-invasive prenatal testing (NIPT), oncology research, and transplant monitoring. Whether samples are processed within hours or after days at ambient temperature, you obtain high-quality cfDNA that faithfully represents the in vivo circulating nucleic acid population.
Key Features & Benefits
| Feature | Benefit |
|---|---|
| Room-temperature stabilization for up to 14 days | No need for refrigeration or immediate plasma processing; supports remote collection, multi-center trials, and flexible laboratory schedules. |
| Minimal gDNA contamination | Prevents leukocyte lysis and limits gDNA release to <2% of total DNA throughout the stability window, ensuring robust allele frequency measurements and copy-number analysis. |
| Formaldehyde-free, non-toxic additive | Safe for users and fully compatible with standard enzymatic reactions (qPCR, digital PCR, NGS library preparation) without additional purification. |
| Consistent cfDNA recovery | ≥95% of original cfDNA yield maintained after 7 days and ≥90% after 14 days at 15–25 °C. |
| Validated for downstream applications | Demonstrated performance in low-pass whole-genome sequencing, targeted NGS panels, ddPCR mutation detection, and bisulfite conversion-based methylation assays. |
| Ready-to-use vacuum tube | Standard blood collection format; simple inversion mixing protocol; compatible with routine phlebotomy practices. |
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